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-Structure paper
Title | Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance |
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Journal, issue, pages | Chembiochem, Vol. 11, Page 2557-2566, Year 2010 |
Publish date | Feb 4, 2010 (structure data deposition date) |
![]() | Klueter, S. / Simard, J.R. / Rode, H.B. / Gruetter, C. / Pawar, V. / Raaijmakers, H.C. / Barf, T.A. / Rabiller, M. / van Otterlo, W.A.L. / Rauh, D. |
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Methods | X-ray diffraction |
Resolution | 2.48 Å |
Structure data | ![]() PDB-3lok: |
Chemicals | ![]() ChemComp-DJK: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Src kinase domain / drug resistance / irreversible inhibitor / covalent inhibitor / PD168393 / ATP-binding / Kinase / Lipoprotein / Myristate / Nucleotide-binding / Phosphoprotein / Proto-oncogene / SH2 domain / SH3 domain / Tyrosine-protein kinase / TRANSFERASE-TRANSFERASE INHIBITOR complex |