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-Structure paper
Title | Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 2119-2124, Year 2010 |
Publish date | Jan 27, 2010 (structure data deposition date) |
Authors | Cheng, C.C. / Shipps, G.W. / Yang, Z. / Kawahata, N. / Lesburg, C.A. / Duca, J.S. / Bandouveres, J. / Bracken, J.D. / Jiang, C.K. / Agrawal, S. ...Cheng, C.C. / Shipps, G.W. / Yang, Z. / Kawahata, N. / Lesburg, C.A. / Duca, J.S. / Bandouveres, J. / Bracken, J.D. / Jiang, C.K. / Agrawal, S. / Ferrari, E. / Huang, H.C. |
External links | Bioorg. Med. Chem. Lett. / PubMed:20219368 |
Methods | X-ray diffraction |
Resolution | 2.05 Å |
Structure data | PDB-3lkh: |
Chemicals | ChemComp-LT6: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / HCV / NS5B / POLYMERASE / Acetylation / Apoptosis / ATP-binding / Capsid protein / Envelope protein / Fusion protein / Glycoprotein / Helicase / Host cell membrane / Host cytoplasm / Host endoplasmic reticulum / Host lipid droplet / Host membrane / Host mitochondrion / Host nucleus / Host-virus interaction / Hydrolase / Interferon antiviral system evasion / Lipoprotein / Membrane / Metal-binding / Multifunctional enzyme / Nucleotide-binding / Nucleotidyltransferase / Oncogene / Palmitate / Phosphoprotein / Protease / Ribonucleoprotein / RNA replication / RNA-binding / RNA-directed RNA polymerase / Secreted / Serine protease / SH3-binding / Thiol protease / Transcription / Transcription regulation / Transmembrane / Ubl conjugation / Viral nucleoprotein / Virion / Zinc |