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-Structure paper
Title | Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 2973-2985, Year 2010 |
Publish date | Jan 22, 2010 (structure data deposition date) |
![]() | Pettus, L.H. / Wurz, R.P. / Xu, S. / Herberich, B. / Henkle, B. / Liu, Q. / McBride, H.J. / Mu, S. / Plant, M.H. / Saris, C.J. ...Pettus, L.H. / Wurz, R.P. / Xu, S. / Herberich, B. / Henkle, B. / Liu, Q. / McBride, H.J. / Mu, S. / Plant, M.H. / Saris, C.J. / Sherman, L. / Wong, L.M. / Chmait, S. / Lee, M.R. / Mohr, C. / Hsieh, F. / Tasker, A.S. |
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Methods | X-ray diffraction |
Resolution | 3.31 Å |
Structure data | ![]() PDB-3lhj: |
Chemicals | ![]() ChemComp-LHJ: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Serine/Threonine-Protein Kinase / Alternative splicing / ATP-binding / Cytoplasm / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism |