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Structure paper

TitleNear-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Journal, issue, pagesActa Crystallogr. ,Sect. D, Vol. 66, Page 714-724, Year 2010
Publish dateJan 4, 2010 (structure data deposition date)
AuthorsGabison, L. / Chiadmi, M. / El Hajji, M. / Castro, B. / Colloc'h, N. / Prange, T.
External linksActa Crystallogr. ,Sect. D / PubMed:20516624
MethodsX-ray diffraction
Resolution1 - 1.75 Å
Structure data

PDB-3l8w:
Urate oxidase from aspergillus flavus complexed with xanthin
Method: X-RAY DIFFRACTION / Resolution: 1 Å

PDB-3l9g:
Urate oxidase complexed with uric acid and chloride
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-3lbg:
Urate oxidase complexed with 8-thio xanthine
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-3ld4:
Urate oxidase complexed with 8-nitro xanthine
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

Chemicals

ChemComp-XAN:
XANTHINE

ChemComp-NA:
Unknown entry

ChemComp-4PO:
alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone

ChemComp-HOH:
WATER

ChemComp-URC:
URIC ACID

ChemComp-MRD:
(4R)-2-METHYLPENTANE-2,4-DIOL / precipitant*YM

ChemComp-CL:
Unknown entry

ChemComp-8TX:
8-thioxo-3,7,8,9-tetrahydro-1H-purine-2,6-dione

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-8NX:
8-nitro-3,7-dihydro-1H-purine-2,6-dione

Source
  • aspergillus flavus (mold)
KeywordsOXIDOREDUCTASE / URIC ACID DEGRADATION / XANTHINE / INHIBITION ASPERGILLUS FLAVUS / Peroxisome / Purine metabolism / URATE OXIDASE / HIGH RESOLUTION / URIC ACID / ASPERGILLUS FLAVUS / NITROXANTHINE / 8-THIOXANTHINE / THIOXANTHINE / PROTONATION

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