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-Structure paper
Title | Therapeutic antibody targeting of individual Notch receptors. |
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Journal, issue, pages | Nature, Vol. 464, Page 1052-1057, Year 2010 |
Publish date | Jan 4, 2010 (structure data deposition date) |
![]() | Wu, Y. / Cain-Hom, C. / Choy, L. / Hagenbeek, T.J. / de Leon, G.P. / Chen, Y. / Finkle, D. / Venook, R. / Wu, X. / Ridgway, J. ...Wu, Y. / Cain-Hom, C. / Choy, L. / Hagenbeek, T.J. / de Leon, G.P. / Chen, Y. / Finkle, D. / Venook, R. / Wu, X. / Ridgway, J. / Schahin-Reed, D. / Dow, G.J. / Shelton, A. / Stawicki, S. / Watts, R.J. / Zhang, J. / Choy, R. / Howard, P. / Kadyk, L. / Yan, M. / Zha, J. / Callahan, C.A. / Hymowitz, S.G. / Siebel, C.W. |
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Methods | X-ray diffraction |
Resolution | 2.19 Å |
Structure data | ![]() PDB-3l95: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-CA: ![]() ChemComp-HOH: |
Source |
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![]() | IMMUNE SYSTEM / NRR / fab fragment / antibody / ALPHA-BETA-SANDWICH / SEA DOMAIN / LNR / LIN12 NOTCH CYSTEINE-RICH / HD DOMAIN / CELL CYCLE / SIGNALING PROTEIN / Activator / ANK repeat / Cell membrane / Developmental protein / Differentiation / EGF-like domain / Glycoprotein / Membrane / Metal-binding / Notch signaling pathway |