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| Title | Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin. |
|---|---|
| Journal, issue, pages | ACS Med Chem Lett, Vol. 1, Page 39-43, Year 2010 |
| Publish date | Dec 9, 2009 (structure data deposition date) |
 Authors | Knight, S.D. / Adams, N.D. / Burgess, J.L. / Chaudhari, A.M. / Darcy, M.G. / Donatelli, C.A. / Luengo, J.I. / Newlander, K.A. / Parrish, C.A. / Ridgers, L.H. ...Knight, S.D. / Adams, N.D. / Burgess, J.L. / Chaudhari, A.M. / Darcy, M.G. / Donatelli, C.A. / Luengo, J.I. / Newlander, K.A. / Parrish, C.A. / Ridgers, L.H. / Sarpong, M.A. / Schmidt, S.J. / Van Aller, G.S. / Carson, J.D. / Diamond, M.A. / Elkins, P.A. / Gardiner, C.M. / Garver, E. / Gilbert, S.A. / Gontarek, R.R. / Jackson, J.R. / Kershner, K.L. / Luo, L. / Raha, K. / Sherk, C.S. / Sung, C.M. / Sutton, D. / Tummino, P.J. / Wegrzyn, R.J. / Auger, K.R. / Dhanak, D. |
 External links | ACS Med Chem Lett / PubMed:24900173 |
| Methods | X-ray diffraction |
| Resolution | 2.3 - 2.7 Å |
| Structure data |  PDB-3l08:  PDB-3l54: |
| Chemicals |  ChemComp-SO4:  ChemComp-ZIG:  ChemComp-HOH:  ChemComp-LXX: |
| Source |
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 Keywords | TRANSFERASE / Pi3K gamma / lipid kinase / phosphoinositide / inhibitor / GSK2126458 / signaling / kinase / ATP-binding / Nucleotide-binding / Pi3K / phosphatidylinositol / Pi3 |
homo sapiens (human)