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-Structure paper
Title | Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 1023-1026, Year 2010 |
Publish date | Dec 17, 2009 (structure data deposition date) |
Authors | Gandhi, V.B. / Luo, Y. / Liu, X. / Shi, Y. / Klinghofer, V. / Johnson, E.F. / Park, C. / Giranda, V.L. / Penning, T.D. / Zhu, G.D. |
External links | Bioorg. Med. Chem. Lett. / PubMed:20045315 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-3l3l: |
Chemicals | ChemComp-L3L: ChemComp-HOH: |
Source |
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Keywords | Transferase/Transferase Inhibitor / Protein-Inhibitor Complex / ADP-ribosylation / DNA damage / DNA repair / DNA-binding / Glycosyltransferase / Metal-binding / NAD / Nucleus / Phosphoprotein / Transcription / Transcription regulation / Transferase / Transferase-Transferase Inhibitor complex |