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-Structure paper
Title | Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 2068-2073, Year 2010 |
Publish date | Dec 16, 2009 (structure data deposition date) |
![]() | Malamas, M.S. / Barnes, K. / Hui, Y. / Johnson, M. / Lovering, F. / Condon, J. / Fobare, W. / Solvibile, W. / Turner, J. / Hu, Y. ...Malamas, M.S. / Barnes, K. / Hui, Y. / Johnson, M. / Lovering, F. / Condon, J. / Fobare, W. / Solvibile, W. / Turner, J. / Hu, Y. / Manas, E.S. / Fan, K. / Olland, A. / Chopra, R. / Bard, J. / Pangalos, M.N. / Reinhart, P. / Robichaud, A.J. |
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Methods | X-ray diffraction |
Resolution | 2.1 - 2.362 Å |
Structure data | ![]() PDB-3l38: ![]() PDB-3l3a: |
Chemicals | ![]() ChemComp-879: ![]() ChemComp-HOH: ![]() ChemComp-625: |
Source |
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![]() | HYDROLASE / beta-secretase / bace-1 / aminopyridine / inhibitor / Aspartyl protease / Disulfide bond / Protease / Transmembrane / Zymogen |