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-Structure paper
| Title | Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 20, Page 1524-1527, Year 2010 |
| Publish date | Dec 1, 2009 (structure data deposition date) |
 Authors | Rankovic, Z. / Cai, J. / Kerr, J. / Fradera, X. / Robinson, J. / Mistry, A. / Hamilton, E. / McGarry, G. / Andrews, F. / Caulfield, W. ...Rankovic, Z. / Cai, J. / Kerr, J. / Fradera, X. / Robinson, J. / Mistry, A. / Hamilton, E. / McGarry, G. / Andrews, F. / Caulfield, W. / Cumming, I. / Dempster, M. / Waller, J. / Scullion, P. / Martin, I. / Mitchell, A. / Long, C. / Baugh, M. / Westwood, P. / Kinghorn, E. / Bruin, J. / Hamilton, W. / Uitdehaag, J. / van Zeeland, M. / Potin, D. / Saniere, L. / Fouquet, A. / Chevallier, F. / Deronzier, H. / Dorleans, C. / Nicolai, E. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:20149657 |
| Methods | X-ray diffraction |
| Resolution | 1.49 - 1.8 Å |
| Structure data |  PDB-3kw9:  PDB-3kwz:  PDB-3kx1: |
| Chemicals |  ChemComp-ORG:  ChemComp-TFA:  ChemComp-HOH:  ChemComp-SO4:  ChemComp-KWZ:  ChemComp-KX1: |
| Source |
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 Keywords | HYDROLASE / cysteine / thioimidate / Disulfide bond / cys protease / inhibitor / non-peptide / Protease / Thiol protease / Zymogen / cathepsin K / enzyme inhibitor / covalent reversible inhibitor / Disease mutation / Glycoprotein / Lysosome |
homo sapiens (human)