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-Structure paper
Title | Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 336-346, Year 2009 |
Publish date | Nov 12, 2009 (structure data deposition date) |
![]() | Venkatraman, S. / Velazquez, F. / Wu, W. / Blackman, M. / Chen, K.X. / Bogen, S. / Nair, L. / Tong, X. / Chase, R. / Hart, A. ...Venkatraman, S. / Velazquez, F. / Wu, W. / Blackman, M. / Chen, K.X. / Bogen, S. / Nair, L. / Tong, X. / Chase, R. / Hart, A. / Agrawal, S. / Pichardo, J. / Prongay, A. / Cheng, K.C. / Girijavallabhan, V. / Piwinski, J. / Shih, N.Y. / Njoroge, F.G. |
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Methods | X-ray diffraction |
Resolution | 2.65 Å |
Structure data | ![]() PDB-3knx: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-JZT: ![]() ChemComp-BME: ![]() ChemComp-HOH: |
Source |
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![]() | VIRAL PROTEIN / Hepatitis C Virus / NS3 Protease Domain / serine protease / macrocyclic ketoamide inhibitor / ATP-binding / Envelope protein / Helicase / Hydrolase / Membrane / Nucleotide-binding / RNA replication / Transmembrane |