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Title17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production.
Journal, issue, pagesMol. Endocrinol., Vol. 24, Page 832-845, Year 2010
Publish dateNov 8, 2009 (structure data deposition date)
AuthorsAka, J.A. / Mazumdar, M. / Chen, C.Q. / Poirier, D. / Lin, S.X.
External linksMol. Endocrinol. / PubMed:20172961
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-3klm:
17beta-HSD1 in complex with DHT
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-DHT:
5-ALPHA-DIHYDROTESTOSTERONE / hormone*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / DHT / Lipid synthesis / Steroid biosynthesis

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