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TitleCrystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.
Journal, issue, pagesTo be Published
Publish dateNov 6, 2009 (structure data deposition date)
AuthorsCheng, R.K.Y. / Crawley, L. / Barker, J. / Whittaker, M.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.48 Å
Structure data

PDB-3kkt:
Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509.
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-0CP:
5-{3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl}tetrahydropyrimidin-2(1H)-one / inhibitor*YM

ChemComp-MG:
Unknown entry

ChemComp-B3P:
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PHOSPHODIESTERASE / ALTERNATIVE SPLICING / Phosphoprotein

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