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-Structure paper
Title | Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 107, Page 28-33, Year 2010 |
Publish date | Nov 4, 2009 (structure data deposition date) |
Authors | Rimon, G. / Sidhu, R.S. / Lauver, D.A. / Lee, J.Y. / Sharma, N.P. / Yuan, C. / Frieler, R.A. / Trievel, R.C. / Lucchesi, B.R. / Smith, W.L. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:19955429 |
Methods | X-ray diffraction |
Resolution | 2.75 Å |
Structure data | PDB-3kk6: |
Chemicals | ChemComp-HEM: ChemComp-CEL: ChemComp-BOG: ChemComp-FLC: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / cox-1 / cyclooxygenase / peroxidase / prostaglandin / heme / celecoxib / merohedral twinned / Dioxygenase / Disulfide bond / EGF-like domain / Endoplasmic reticulum / Fatty acid biosynthesis / Glycoprotein / Iron / Lipid synthesis / Membrane / Metal-binding / Microsome / Prostaglandin biosynthesis / Transmembrane |