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Title | Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors. |
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Journal, issue, pages | Biochim. Biophys. Acta, Vol. 1804, Page 1817-1831, Year 2010 |
Publish date | Nov 3, 2009 (structure data deposition date) |
![]() | Wang, Z. / Watt, W. / Brooks, N.A. / Harris, M.S. / Urban, J. / Boatman, D. / McMillan, M. / Kahn, M. / Heinrikson, R.L. / Finzel, B.C. ...Wang, Z. / Watt, W. / Brooks, N.A. / Harris, M.S. / Urban, J. / Boatman, D. / McMillan, M. / Kahn, M. / Heinrikson, R.L. / Finzel, B.C. / Wittwer, A.J. / Blinn, J. / Kamtekar, S. / Tomasselli, A.G. |
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Methods | X-ray diffraction |
Resolution | 1.8 - 2 Å |
Structure data | ![]() PDB-3kjf: ![]() PDB-3kjn: ![]() PDB-3kjq: |
Chemicals | ![]() ChemComp-B92: ![]() ChemComp-HOH: ![]() ChemComp-DTT: ![]() ChemComp-B93: ![]() ChemComp-B94: |
Source |
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![]() | HYDROLASE / caspase 3 / Apoptosis / kinetics / Peptidomimetic Inhibitor / urazole / Phosphoprotein / Protease / S-nitrosylation / Thiol protease / Zymogen / HYDROLASE/HYDROLASE INHIBITOR / caspase 8 / HYDROLASE-HYDROLASE INHIBITOR complex / Disease mutation / Allosteric |