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| Title | Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 53, Page 2854-2864, Year 2010 |
| Publish date | Oct 23, 2009 (structure data deposition date) |
 Authors | Li, J. / Kennedy, L.J. / Shi, Y. / Tao, S. / Ye, X.Y. / Chen, S.Y. / Wang, Y. / Hernandez, A.S. / Wang, W. / Devasthale, P.V. ...Li, J. / Kennedy, L.J. / Shi, Y. / Tao, S. / Ye, X.Y. / Chen, S.Y. / Wang, Y. / Hernandez, A.S. / Wang, W. / Devasthale, P.V. / Chen, S. / Lai, Z. / Zhang, H. / Wu, S. / Smirk, R.A. / Bolton, S.A. / Ryono, D.E. / Lim, N.K. / Chen, B.C. / Locke, K.T. / O'Malley, K.M. / Zhang, L. / Srivastava, R.A. / Miao, B. / Meyers, D.S. / Monshizadegan, H. / Search, D. / Grimm, D. / Zhang, R. / Harrity, T. / Kunselman, L.K. / Cap, M. / Kadiyala, P. / Hosagrahara, V. / Xu, C. / Li, Y.X. / Muckelbauer, J.K. / Chang, C. / An, Y. / Krystek, S.R. / Blanar, M.A. / Zahler, R. / Mukherjee, R. / Cheng, P.T. / Tino, J.A. |
 External links | J. Med. Chem. / PubMed:20218621 |
| Methods | X-ray diffraction |
| Resolution | 2.07 - 2.7 Å |
| Structure data |  PDB-3kdt:  PDB-3kdu: |
| Chemicals |  ChemComp-7HA:  ChemComp-HOH:  ChemComp-NKS: |
| Source |
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 Keywords | HORMONE RECEPTOR / Nuclear Hormone Receptor / transcription regulation / Activator / DNA-binding / Lipid-binding / Receptor / Transcription |
homo sapiens (human)