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TitleCrystal structures of human FIH-1 in complex with quinol family inhibitors
Journal, issue, pagesMol. Cells, Vol. 29, Page 471-474, Year 2010
Publish dateOct 22, 2009 (structure data deposition date)
AuthorsMoon, H. / Han, S. / Park, H. / Choe, J.
External linksMol. Cells / PubMed:20396966
MethodsX-ray diffraction
Resolution2.59 - 2.6 Å
Structure data

PDB-3kcx:
Factor inhibiting HIF-1 alpha in complex with Clioquinol
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-3kcy:
Factor inhibiting HIF-1 alpha in complex with 8-hydroxyquinoline
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CQL:
5-chloro-7-iodoquinolin-8-ol / antifungal*YM

ChemComp-HOH:
WATER

ChemComp-HQY:
quinolin-8-ol

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / hypoxia / HIF-1 / FIH-1 / inhibitor / Dioxygenase / Iron / Metal-binding / Nucleus / Transcription / Transcription regulation

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