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TitleCrystal structure of human purine nucleoside phosphorylase in complex with DATMe-Immucillin H
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Year 2010
Publish dateOct 14, 2009 (structure data deposition date)
AuthorsHo, M. / Rinaldo-matthis, A. / Almo, S.C. / Schramm, V.L.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-3k8o:
Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-229:
7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL]AMINO}METHYL)-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / transition state analog inhibitor / DATMe-ImmH / hPNP / PNP / purine nucleoside phosphorylase / Cytoskeleton / Disease mutation / Glycosyltransferase

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