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-Structure paper
Title | Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 7950-7953, Year 2009 |
Publish date | Oct 7, 2009 (structure data deposition date) |
![]() | Liu, F. / Chen, X. / Allali-Hassani, A. / Quinn, A.M. / Wasney, G.A. / Dong, A. / Barsyte, D. / Kozieradzki, I. / Senisterra, G. / Chau, I. ...Liu, F. / Chen, X. / Allali-Hassani, A. / Quinn, A.M. / Wasney, G.A. / Dong, A. / Barsyte, D. / Kozieradzki, I. / Senisterra, G. / Chau, I. / Siarheyeva, A. / Kireev, D.B. / Jadhav, A. / Herold, J.M. / Frye, S.V. / Arrowsmith, C.H. / Brown, P.J. / Simeonov, A. / Vedadi, M. / Jin, J. |
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Methods | X-ray diffraction |
Resolution | 1.7 Å |
Structure data | ![]() PDB-3k5k: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-SAH: ![]() ChemComp-DXQ: ![]() ChemComp-CL: ![]() ChemComp-UNX: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Histone Lysine Methyltransferase / G9A / ANK repeat / Chromatin regulator / Metal-binding / Methyltransferase / Nucleus / Phosphoprotein / S-adenosyl-L-methionine / Structural Genomics / Structural Genomics Consortium / SGC |