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TitleMacrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 20, Page 603-607, Year 2010
Publish dateOct 7, 2009 (structure data deposition date)
AuthorsLerchner, A. / Machauer, R. / Betschart, C. / Veenstra, S. / Rueeger, H. / McCarthy, C. / Tintelnot-Blomley, M. / Jaton, A.L. / Rabe, S. / Desrayaud, S. ...Lerchner, A. / Machauer, R. / Betschart, C. / Veenstra, S. / Rueeger, H. / McCarthy, C. / Tintelnot-Blomley, M. / Jaton, A.L. / Rabe, S. / Desrayaud, S. / Enz, A. / Staufenbiel, M. / Paganetti, P. / Rondeau, J.M. / Neumann, U.
External linksBioorg. Med. Chem. Lett. / PubMed:19963375
MethodsX-ray diffraction
Resolution2.12 Å
Structure data

PDB-3k5c:
Human BACE-1 complex with NB-216
Method: X-RAY DIFFRACTION / Resolution: 2.12 Å

Chemicals

ChemComp-0BI:
(4S)-4-[(1R)-1-hydroxy-2-({1-[3-(1-methylethyl)phenyl]cyclopropyl}amino)ethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatric

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / aspartyl proteinase; alzheimer's disease / Aspartyl protease / Disulfide bond / Endoplasmic reticulum / Endosome / Glycoprotein / Golgi apparatus / Hydrolase-Hydrolase inhibitor complex / Membrane / Protease / Transmembrane

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