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Title | The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay. |
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Journal, issue, pages | Chem. Biol. Drug Des., Vol. 74, Page 547-559, Year 2009 |
Publish date | Oct 2, 2009 (structure data deposition date) |
Authors | Tecle, H. / Feru, F. / Liu, H. / Kuhn, C. / Rennie, G. / Morris, M. / Shao, J. / Cheng, A.C. / Gikunju, D. / Miret, J. ...Tecle, H. / Feru, F. / Liu, H. / Kuhn, C. / Rennie, G. / Morris, M. / Shao, J. / Cheng, A.C. / Gikunju, D. / Miret, J. / Coli, R. / Xi, S.H. / Clugston, S.L. / Low, S. / Kazmirski, S. / Ding, Y.H. / Cao, Q. / Johnson, T.L. / Deshmukh, G.D. / DiNitto, J.P. / Wu, J.C. / English, J.M. |
External links | Chem. Biol. Drug Des. / PubMed:19843080 |
Methods | X-ray diffraction |
Resolution | 1.7 - 1.995 Å |
Structure data | PDB-3k3i: PDB-3k3j: |
Chemicals | ChemComp-JZJ: ChemComp-I46: ChemComp-HOH: ChemComp-F4C: |
Source |
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Keywords | TRANSFERASE / P38 Kinase / Alternative splicing / ATP-binding / Cytoplasm / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase / p38alpha kinase |