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TitleCryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.
Journal, issue, pagesScience, Vol. 342, Issue 6165, Page 1484-1490, Year 2013
Publish dateDec 20, 2013
AuthorsDmitry Lyumkis / Jean-Philippe Julien / Natalia de Val / Albert Cupo / Clinton S Potter / Per-Johan Klasse / Dennis R Burton / Rogier W Sanders / John P Moore / Bridget Carragher / Ian A Wilson / Andrew B Ward /
PubMed AbstractThe HIV-1 envelope glycoprotein (Env) trimer contains the receptor binding sites and membrane fusion machinery that introduce the viral genome into the host cell. As the only target for broadly ...The HIV-1 envelope glycoprotein (Env) trimer contains the receptor binding sites and membrane fusion machinery that introduce the viral genome into the host cell. As the only target for broadly neutralizing antibodies (bnAbs), Env is a focus for rational vaccine design. We present a cryo-electron microscopy reconstruction and structural model of a cleaved, soluble Env trimer (termed BG505 SOSIP.664 gp140) in complex with a CD4 binding site (CD4bs) bnAb, PGV04, at 5.8 angstrom resolution. The structure reveals the spatial arrangement of Env components, including the V1/V2, V3, HR1, and HR2 domains, as well as shielding glycans. The structure also provides insights into trimer assembly, gp120-gp41 interactions, and the CD4bs epitope cluster for bnAbs, which covers a more extensive area and defines a more complex site of vulnerability than previously described.
External linksScience / PubMed:24179160 / PubMed Central
MethodsEM (single particle)
Resolution5.8 - 12.7 Å
Structure data

5779

3j5m

EMDB-5779, PDB-3j5m:
Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 3 PGV04 Fabs
Method: EM (single particle) / Resolution: 5.8 Å

EMDB-5780:
Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer with 2 PGV04 Fabs
Method: EM (single particle) / Resolution: 7.9 Å

EMDB-5781:
Cryo-EM structure of the BG505 SOSIP.650 HIV-1 Env trimer with 3 PGV04 Fabs
Method: EM (single particle) / Resolution: 8.2 Å

EMDB-5782:
Cryo-EM structure of the BG505 SOSIP.664 HIV-1 Env trimer
Method: EM (single particle) / Resolution: 12.7 Å

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 trimeric spike / gp140 / SOSIP / broadly neutralizing antibody / PGV04 / Env / envelope glycoprotein / VIRAL PROTEIN-IMMUNE SYSTEM complex

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