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-Structure paper
Title | Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 45, Page 870-882, Year 2010 |
Publish date | Sep 4, 2009 (structure data deposition date) |
![]() | Wangsell, F. / Gustafsson, K. / Kvarnstrom, I. / Borkakoti, N. / Edlund, M. / Jansson, K. / Lindberg, J. / Hallberg, A. / Rosenquist, A. / Samuelsson, B. |
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Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | ![]() PDB-3ixk: |
Chemicals | ![]() ChemComp-929: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / BACE / beta-secretase / statine / inhibitor / aspartyl protease / glycoprotein / membrane / protease / transmembrane / ZYMOGEN / Disulfide bond |