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-Structure paper
Title | Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for chagas disease chemotherapy. |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 1763-1773, Year 2010 |
Publish date | Aug 31, 2009 (structure data deposition date) |
Authors | Brak, K. / Kerr, I.D. / Barrett, K.T. / Fuchi, N. / Debnath, M. / Ang, K. / Engel, J.C. / McKerrow, J.H. / Doyle, P.S. / Brinen, L.S. / Ellman, J.A. |
External links | J. Med. Chem. / PubMed:20088534 |
Methods | X-ray diffraction |
Resolution | 1.2 Å |
Structure data | PDB-3iut: |
Chemicals | ChemComp-KB2: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / mature domain / papain family cysteine protease / Autocatalytic cleavage / Disulfide bond / Glycoprotein / Protease / Thiol protease / Zymogen |