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| Title | 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 6529-6533, Year 2009 |
| Publish date | Aug 13, 2009 (structure data deposition date) |
 Authors | Ledeboer, M.W. / Pierce, A.C. / Duffy, J.P. / Gao, H. / Messersmith, D. / Salituro, F.G. / Nanthakumar, S. / Come, J. / Zuccola, H.J. / Swenson, L. ...Ledeboer, M.W. / Pierce, A.C. / Duffy, J.P. / Gao, H. / Messersmith, D. / Salituro, F.G. / Nanthakumar, S. / Come, J. / Zuccola, H.J. / Swenson, L. / Shlyakter, D. / Mahajan, S. / Hoock, T. / Fan, B. / Tsai, W.J. / Kolaczkowski, E. / Carrier, S. / Hogan, J.K. / Zessis, R. / Pazhanisamy, S. / Bennani, Y.L. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:19857967 |
| Methods | X-ray diffraction |
| Resolution | 2.1 - 2.6 Å |
| Structure data |  PDB-3io7:  PDB-3iok: |
| Chemicals |  ChemComp-1P5:  ChemComp-HOH:  ChemComp-1P6: |
| Source |
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 Keywords | TRANSFERASE / kinase / inhibitor / jak2 / janus kinase / ATP-binding / Chromosomal rearrangement / Disease mutation / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Proto-oncogene / SH2 domain / Tyrosine-protein kinase |
homo sapiens (human)