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-Structure paper
Title | Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase |
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Journal, issue, pages | To be Published |
Publish date | Aug 13, 2009 (structure data deposition date) |
Authors | Chitnumsub, P. / Yuvaniyama, J. / Vilaivan, T. / Vanichtanankul, J. / Kamchonwongpaisan, S. / Yuthavong, Y. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.1 - 2.8 Å |
Structure data | PDB-3inv: PDB-3irm: PDB-3irn: PDB-3iro: |
Chemicals | ChemComp-C50: ChemComp-NDP: ChemComp-UMP: ChemComp-GOL: ChemComp-HOH: ChemComp-1CY: ChemComp-PO4: ChemComp-ACT: ChemComp-2CY: |
Source |
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Keywords | OXIDOREDUCTASE/TRANSFERASE / DHFR-TS antifolate complex / Methyltransferase / Multifunctional enzyme / NADP / Nucleotide biosynthesis / One-carbon metabolism / Oxidoreductase / Transferase / OXIDOREDUCTASE-TRANSFERASE COMPLEX / Trypanosoma cruzi |