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Title | AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. |
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Journal, issue, pages | Cancer Cell, Vol. 16, Page 401-412, Year 2009 |
Publish date | Aug 5, 2009 (structure data deposition date) |
Authors | O'Hare, T. / Shakespeare, W.C. / Zhu, X. / Eide, C.A. / Rivera, V.M. / Wang, F. / Adrian, L.T. / Zhou, T. / Huang, W.S. / Xu, Q. ...O'Hare, T. / Shakespeare, W.C. / Zhu, X. / Eide, C.A. / Rivera, V.M. / Wang, F. / Adrian, L.T. / Zhou, T. / Huang, W.S. / Xu, Q. / Metcalf, C.A. / Tyner, J.W. / Loriaux, M.M. / Corbin, A.S. / Wardwell, S. / Ning, Y. / Keats, J.A. / Wang, Y. / Sundaramoorthi, R. / Thomas, M. / Zhou, D. / Snodgrass, J. / Commodore, L. / Sawyer, T.K. / Dalgarno, D.C. / Deininger, M.W. / Druker, B.J. / Clackson, T. |
External links | Cancer Cell / PubMed:19878872 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3ik3: |
Chemicals | ChemComp-0LI: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Bcr-Abl / CML / T315I / inhibitor / mutation / drug resistance / Alternative splicing / ATP-binding / Cell adhesion / Chromosomal rearrangement / Cytoplasm / Cytoskeleton / Kinase / Lipoprotein / Magnesium / Manganese / Metal-binding / Myristate / Nucleotide-binding / Nucleus / Phosphoprotein / Proto-oncogene / SH2 domain / SH3 domain |