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TitleAminoimidazoles as potent and selective human beta-secretase (BACE1) inhibitors
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 6314-6323, Year 2009
Publish dateJul 27, 2009 (structure data deposition date)
AuthorsMalamas, M.S. / Erdei, J. / Gunawan, I. / Barnes, K. / Johnson, M. / Hui, Y. / Turner, J. / Hu, Y. / Wagner, E. / Fan, K. ...Malamas, M.S. / Erdei, J. / Gunawan, I. / Barnes, K. / Johnson, M. / Hui, Y. / Turner, J. / Hu, Y. / Wagner, E. / Fan, K. / Olland, A. / Bard, J. / Robichaud, A.J.
External linksJ. Med. Chem. / PubMed:19757823
MethodsX-ray diffraction
Resolution2.238 Å
Structure data

PDB-3igb:
Bace-1 with Compound 3
Method: X-RAY DIFFRACTION / Resolution: 2.238 Å

Chemicals

ChemComp-454:
8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Bace-1 / Amino-imidazoles / inhibitors / Alternative splicing / Aspartyl protease / Disulfide bond / Glycoprotein / Membrane / Polymorphism / Protease / Transmembrane / Zymogen

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