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TitleDiscovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.
Journal, issue, pagesJ. Med. Chem., Vol. 52, Page 7360-7363, Year 2009
Publish dateJul 9, 2009 (structure data deposition date)
AuthorsWittman, M.D. / Carboni, J.M. / Yang, Z. / Lee, F.Y. / Antman, M. / Attar, R. / Balimane, P. / Chang, C. / Chen, C. / Discenza, L. ...Wittman, M.D. / Carboni, J.M. / Yang, Z. / Lee, F.Y. / Antman, M. / Attar, R. / Balimane, P. / Chang, C. / Chen, C. / Discenza, L. / Frennesson, D. / Gottardis, M.M. / Greer, A. / Hurlburt, W. / Johnson, W. / Langley, D.R. / Li, A. / Li, J. / Liu, P. / Mastalerz, H. / Mathur, A. / Menard, K. / Patel, K. / Sack, J. / Sang, X. / Saulnier, M. / Smith, D. / Stefanski, K. / Trainor, G. / Velaparthi, U. / Zhang, G. / Zimmermann, K. / Vyas, D.M.
External linksJ. Med. Chem. / PubMed:19778024
MethodsX-ray diffraction
Resolution2.08 Å
Structure data

PDB-3i81:
Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

Chemicals

ChemComp-EBI:
1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-proli

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE / HORMONE/GROWTH FACTOR / IGF-1R / KINASE DOMAIN / ATP-binding / Disease mutation / Disulfide bond / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Receptor / Transferase / Transmembrane / Tyrosine-protein kinase

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