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Title | Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 7689-7705, Year 2009 |
Publish date | Jul 7, 2009 (structure data deposition date) |
![]() | Ghosh, A.K. / Kulkarni, S. / Anderson, D.D. / Hong, L. / Baldridge, A. / Wang, Y.F. / Chumanevich, A.A. / Kovalevsky, A.Y. / Tojo, Y. / Amano, M. ...Ghosh, A.K. / Kulkarni, S. / Anderson, D.D. / Hong, L. / Baldridge, A. / Wang, Y.F. / Chumanevich, A.A. / Kovalevsky, A.Y. / Tojo, Y. / Amano, M. / Koh, Y. / Tang, J. / Weber, I.T. / Mitsuya, H. |
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Methods | X-ray diffraction |
Resolution | 1.17 - 1.7 Å |
Structure data | ![]() PDB-3i6o: ![]() PDB-3i7e: |
Chemicals | ![]() ChemComp-NA: ![]() ChemComp-IOD: ![]() ChemComp-GOL: ![]() ChemComp-GR6: ![]() ChemComp-HOH: ![]() ChemComp-DJR: |
Source |
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![]() | HYDROLASE / HIV-1 / wild type protease / protease inhibitor / macrocyclic ligand / AIDS / Aspartyl protease / HIV / HIV prtease / HIV-protease inhibitor / drug design / Aspartic protease / acid protease / Structure based drug design / Protease |