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TitleDiscovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 6307-6312, Year 2009
Publish dateJul 6, 2009 (structure data deposition date)
AuthorsBoezio, A.A. / Berry, L. / Albrecht, B.K. / Bauer, D. / Bellon, S.F. / Bode, C. / Chen, A. / Choquette, D. / Dussault, I. / Hirai, S. ...Boezio, A.A. / Berry, L. / Albrecht, B.K. / Bauer, D. / Bellon, S.F. / Bode, C. / Chen, A. / Choquette, D. / Dussault, I. / Hirai, S. / Kaplan-Lefko, P. / Larrow, J.F. / Lin, M.H. / Lohman, J. / Potashman, M.H. / Rex, K. / Santostefano, M. / Shah, K. / Shimanovich, R. / Springer, S.K. / Teffera, Y. / Yang, Y. / Zhang, Y. / Harmange, J.C.
External linksBioorg. Med. Chem. Lett. / PubMed:19819693
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-3i5n:
Crystal structure of c-Met with triazolopyridazine inhibitor 13
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-B2D:
7-methoxy-N-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / proto-oncogene / RTK / receptor tyrosine kinase / scatter factor receptor / HGF/SF / Alternative splicing / ATP-binding / Chromosomal rearrangement / Disease mutation / Disulfide bond / Glycoprotein / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Receptor / Transmembrane / Tyrosine-protein kinase

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