+Search query
-Structure paper
Title | Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core |
---|---|
Journal, issue, pages | Bioorg. Med. Chem., Vol. 18, Page 1711-1723, Year 2010 |
Publish date | Jun 29, 2009 (structure data deposition date) |
Authors | Bjorklund, C. / Adolfsson, H. / Jansson, K. / Lindberg, J. / Vrang, L. / Hallberg, A. / Rosenquist, A. / Samuelsson, B. |
External links | Bioorg. Med. Chem. / PubMed:20122837 |
Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | PDB-3i25: |
Chemicals | ChemComp-MV7: ChemComp-HOH: |
Source |
|
Keywords | HYDROLASE / BACE / BETA-SECRETASE / INHIBITOR / ASPARTYL PROTEASE / PROTEASE / Alternative splicing / Disulfide bond / Glycoprotein / Membrane / Polymorphism / Transmembrane / Zymogen |