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Structure paper

TitleConstruction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
Journal, issue, pagesProtein Eng. Des. Sel., Vol. 21, Page 425-433, Year 2008
Publish dateApr 11, 2008 (structure data deposition date)
AuthorsWang, W. / Prosise, W.W. / Chen, J. / Taremi, S.S. / Le, H.V. / Madison, V. / Cui, X. / Thomas, A. / Cheng, K.C. / Lesburg, C.A.
External linksProtein Eng. Des. Sel. / PubMed:18456871
MethodsX-ray diffraction
Resolution2 - 2.1 Å
Structure data

PDB-3ctb:
Tethered PXR-LBD/SRC-1p apoprotein
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3hvl:
Tethered PXR-LBD/SRC-1p complexed with SR-12813
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SRL:
[2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER

Source
  • homo sapiens (human)
KeywordsTranscription / Transferase / pxr / src-1 / tethered / engineered / drug-drug interactions / DNA-binding / Metal-binding / Nucleus / Receptor / Transcription regulation / Zinc-finger

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