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TitleStructural basis for biosynthetic programming of fungal aromatic polyketide cyclization.
Journal, issue, pagesNature, Vol. 461, Page 1139-1143, Year 2009
Publish dateJun 9, 2009 (structure data deposition date)
AuthorsCrawford, J.M. / Korman, T.P. / Labonte, J.W. / Vagstad, A.L. / Hill, E.A. / Kamari-Bidkorpeh, O. / Tsai, S.C. / Townsend, C.A.
External linksNature / PubMed:19847268
MethodsX-ray diffraction
Resolution1.8 - 1.9 Å
Structure data

PDB-3hrq:
The Product Template Domain from PksA with palmitate bound
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3hrr:
The Product Template Domain from PksA with Harris Compound Bound
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-PLM:
PALMITIC ACID

ChemComp-HOH:
WATER

ChemComp-HC8:
1-(3-acetyl-4,5-dihydroxy-7-methoxynaphthalen-2-yl)propan-2-one

Source
  • aspergillus parasiticus (mold)
KeywordsBIOSYNTHETIC PROTEIN / hot-dog fold / PksA / polyketide synthase / iterative Type I PKS / aflatoxin / norsolorinic acid / product template domain / Acyltransferase / Multifunctional enzyme / Phosphopantetheine / TRANSCRIPTION / polyketide / PKS / Harris Compound / Transferase

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