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-Structure paper
Title | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding |
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Journal, issue, pages | Biochemistry, Vol. 51, Page 2289-2297, Year 2012 |
Publish date | Jun 5, 2009 (structure data deposition date) |
Authors | Huisman, F.H. / Koon, N. / Bulloch, E.M. / Baker, H.M. / Baker, E.N. / Squire, C.J. / Parker, E.J. |
External links | Biochemistry / PubMed:22352945 |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.21 Å |
Structure data | PDB-3hpx: PDB-3rmj: PDB-3u6w: |
Chemicals | ChemComp-NI: ChemComp-GOL: ChemComp-HOH: ChemComp-MN: ChemComp-MG: ChemComp-KIV: |
Source |
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Keywords | TRANSFERASE / 2-isopropylmalate synthase / LeuA / Mycobacterium tuberculosis / truncation mutant / active site domain / TIM barrel / Amino-acid biosynthesis / Branched-chain amino acid biosynthesis / Leucine biosynthesis / Truncation / Neisseria meningitidis / Catalytic Domain / Dimer / Alpha-Ketoisovalerate / Acetyl Coenzyme A |