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-Structure paper
Title | Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists. |
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Journal, issue, pages | Acs Chem. Biol., Vol. 4, Page 557-566, Year 2009 |
Publish date | May 26, 2009 (structure data deposition date) |
![]() | Ndubaku, C. / Varfolomeev, E. / Wang, L. / Zobel, K. / Lau, K. / Elliott, L.O. / Maurer, B. / Fedorova, A.V. / Dynek, J.N. / Koehler, M. ...Ndubaku, C. / Varfolomeev, E. / Wang, L. / Zobel, K. / Lau, K. / Elliott, L.O. / Maurer, B. / Fedorova, A.V. / Dynek, J.N. / Koehler, M. / Hymowitz, S.G. / Tsui, V. / Deshayes, K. / Fairbrother, W.J. / Flygare, J.A. / Vucic, D. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | ![]() PDB-3hl5: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-9JZ: ![]() ChemComp-HOH: |
Source |
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![]() | LIGASE / BIR / IAP / apoptosis / small molecule drug discovery / structure-based drug design / Metal-binding / Phosphoprotein / Protease inhibitor / Thiol protease inhibitor / Ubl conjugation pathway / Zinc-finger |