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-Structure paper
Title | S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 6421-6432, Year 2009 |
Publish date | May 25, 2009 (structure data deposition date) |
Authors | Lopez, M. / Paul, B. / Hofmann, A. / Morizzi, J. / Wu, Q.K. / Charman, S.A. / Innocenti, A. / Vullo, D. / Supuran, C.T. / Poulsen, S.A. |
External links | J. Med. Chem. / PubMed:19827837 |
Methods | X-ray diffraction |
Resolution | 1.7 - 2.36 Å |
Structure data | PDB-3hkn: PDB-3hkq: PDB-3hkt: PDB-3hku: |
Chemicals | ChemComp-ZN: ChemComp-GOL: ChemComp-HOH: ChemComp-1SD: ChemComp-TOR: |
Source |
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Keywords | LYASE / Carbonic anhydrase drug design / Disease mutation / Metal-binding / Acetylation / Cytoplasm / Polymorphism / Zinc |