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-Structure paper
Title | Molecular Basis for the Recognition and Cleavages of Igf-II, Tgf-Alpha, and Amylin by Human Insulin Degrading Enzyme. |
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Journal, issue, pages | J. Mol. Biol., Vol. 395, Page 430-, Year 2010 |
Publish date | Jun 5, 2009 (structure data deposition date) |
Authors | Guo, Q. / Manolopoulou, M. / Bian, Y. / Schilling, A.B. / Tang, W.J. |
External links | J. Mol. Biol. / PubMed:19896952 |
Methods | X-ray diffraction |
Resolution | 2.28 - 2.91 Å |
Structure data | PDB-2wk3: PDB-3e4z: PDB-3e50: PDB-3hgz: |
Chemicals | ChemComp-ZN: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / METAL-BINDING / METALLOPROTEASE / IDE / PROTEASE / AMYLOID-BETA (1-42) / HYDROLASE/HORMONE / IGF-II / DEGRADING / COMPLEX / Alternative splicing / Glycoprotein / Growth factor / Mitogen / Polymorphism / Secreted / HYDROLASE-HORMONE COMPLEX / TGF-ALPHA / Cytoplasm / Zinc / Cell membrane / EGF-like domain / Lipoprotein / Membrane / Palmitate / Transmembrane / Insulin degrading enzyme / Amylin / cystein free / Amidation / Amyloid / Cleavage on pair of basic residues / Disulfide bond / Hormone |