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TitleIdentification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 4088-4091, Year 2009
Publish dateMay 7, 2009 (structure data deposition date)
AuthorsOwen, D.R. / Walker, J.K. / Jon Jacobsen, E. / Freskos, J.N. / Hughes, R.O. / Brown, D.L. / Bell, A.S. / Brown, D.G. / Phillips, C. / Mischke, B.V. ...Owen, D.R. / Walker, J.K. / Jon Jacobsen, E. / Freskos, J.N. / Hughes, R.O. / Brown, D.L. / Bell, A.S. / Brown, D.G. / Phillips, C. / Mischke, B.V. / Molyneaux, J.M. / Fobian, Y.M. / Heasley, S.E. / Moon, J.B. / Stallings, W.C. / Joseph Rogier, D. / Fox, D.N. / Palmer, M.J. / Ringer, T. / Rodriquez-Lens, M. / Cubbage, J.W. / Blevis-Bal, R.M. / Benson, A.G. / Acker, B.A. / Maddux, T.M. / Tollefson, M.B. / Bond, B.R. / Macinnes, A. / Yu, Y.
External linksBioorg. Med. Chem. Lett. / PubMed:19540112
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3hdz:
Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective PDE5 Inhibitors
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-PD6:
5-amino-1-butyl-7-phenyl-1,6-naphthyridin-4(1H)-one

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE5 / PDE-5 / inhibition / Alternative splicing / cAMP / Phosphoprotein / Polymorphism Allosteric enzyme / cGMP / cGMP-binding / Magnesium / Metal-binding / Nucleotide-binding / Zinc

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