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-Structure paper
| Title | Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 4092-4096, Year 2009 |
| Publish date | May 5, 2009 (structure data deposition date) |
 Authors | Hughes, R.O. / Walker, J.K. / Cubbage, J.W. / Fobian, Y.M. / Rogier, D.J. / Heasley, S.E. / Blevis-Bal, R.M. / Benson, A.G. / Owen, D.R. / Jacobsen, E.J. ...Hughes, R.O. / Walker, J.K. / Cubbage, J.W. / Fobian, Y.M. / Rogier, D.J. / Heasley, S.E. / Blevis-Bal, R.M. / Benson, A.G. / Owen, D.R. / Jacobsen, E.J. / Freskos, J.N. / Molyneaux, J.M. / Brown, D.L. / Stallings, W.C. / Acker, B.A. / Maddux, T.M. / Tollefson, M.B. / Williams, J.M. / Moon, J.B. / Mischke, B.V. / Rumsey, J.M. / Zheng, Y. / Macinnes, A. / Bond, B.R. / Yu, Y. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:19539468 |
| Methods | X-ray diffraction |
| Resolution | 1.79 Å |
| Structure data |  PDB-3hc8: |
| Chemicals |  ChemComp-PD4:  ChemComp-ZN:  ChemComp-MG:  ChemComp-HOH: |
| Source |
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 Keywords | HYDROLASE / PDE5 / PDE-5 / inhibition / Alternative splicing / cAMP / Phosphoprotein / Polymorphism Allosteric enzyme / cGMP / cGMP-binding / Magnesium / Metal-binding / Nucleotide-binding / Zinc |
homo sapiens (human)