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-Structure paper
Title | Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 3253-3258, Year 2009 |
Publish date | Apr 16, 2009 (structure data deposition date) |
![]() | Walker, D.P. / Zawistoski, M.P. / McGlynn, M.A. / Li, J.C. / Kung, D.W. / Bonnette, P.C. / Baumann, A. / Buckbinder, L. / Houser, J.A. / Boer, J. ...Walker, D.P. / Zawistoski, M.P. / McGlynn, M.A. / Li, J.C. / Kung, D.W. / Bonnette, P.C. / Baumann, A. / Buckbinder, L. / Houser, J.A. / Boer, J. / Mistry, A. / Han, S. / Xing, L. / Guzman-Perez, A. |
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Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | ![]() PDB-3h3c: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-P1E: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / PYK2 / Kinase / Alternative splicing / ATP-binding / Cell membrane / Cytoplasm / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Tyrosine-protein kinase |