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-Structure paper
| Title | Discovery of b-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV |
|---|---|
| Journal, issue, pages | To be Published |
| Publish date | Apr 9, 2009 (structure data deposition date) |
Authors | Nordhoff, S. / Cerezo-Galvez, S. / Deppe, H. / Hill, O. / Lopez-Canet, M. / Rummey, C. / Thiemann, M. / Matassa, V.G. / Edwards, P.J. / Feurer, A. |
External links | Search PubMed |
| Methods | X-ray diffraction |
| Resolution | 2.66 Å |
| Structure data | ![]() PDB-3h0c: |
| Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-PS4: ![]() ChemComp-HOH: |
| Source |
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Keywords | HYDROLASE / COMPLEX (HYDROLASE-INHIBITOR) / DPP-IV / DIABETES MELLITUS / DRUG DESIGN / SERINE PROTEASE / AMINOPEPTIDASE / GLYCOPROTEIN / PROTEASE / SIGNAL-ANCHOR / TRANSMEMBRANE / Cell membrane / Disulfide bond / Membrane / Secreted |
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homo sapiens (human)
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