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TitleNovel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis
Journal, issue, pagesPlos One, Vol. 4, Page e6290-e6290, Year 2009
Publish dateMar 12, 2009 (structure data deposition date)
AuthorsPalaninathan, S.K. / Mohamedmohaideen, N.N. / Orlandini, E. / Ortore, G. / Nencetti, S. / Lapucci, A. / Rossello, A. / Freundlich, J.S. / Sacchettini, J.C.
External linksPlos One / PubMed:19621084
MethodsX-ray diffraction
Resolution1.78 - 1.85 Å
Structure data

PDB-3glz:
Human Transthyretin (TTR) complexed with(E)-3-(2-(trifluoromethyl)benzylideneaminooxy)propanoic acid (inhibitor 11)
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-3gs0:
Human transthyretin (TTR) complexed with (S)-3-(9H-fluoren-9-ylideneaminooxy)-2-methylpropanoic acid (inhibitor 16)
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-3gs4:
Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid (inhibitor 15)
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-3gs7:
Human transthyretin (TTR) complexed with (E)-3-(2-methoxybenzylideneaminooxy)propanoic acid (inhibitor 13)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-1BD:
3-[({(1E)-[2-(trifluoromethyl)phenyl]methylidene}amino)oxy]propanoic acid

ChemComp-HOH:
WATER

ChemComp-6BD:
(2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid

ChemComp-7BD:
3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid

ChemComp-8BD:
3-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acid

Source
  • homo sapiens (human)
KeywordsHORMONE / TTR / AMYLOID / TRANSTHYRETIN / inhibitor / Amyloidosis / Disease mutation / Gamma-carboxyglutamic acid / Glycoprotein / Neuropathy / Polymorphism / Retinol-binding / Secreted / Thyroid hormone / Transport / Vitamin A

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