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TitleAntibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
Journal, issue, pagesJ. Clin. Invest., Vol. 119, Page 1216-1229, Year 2009
Publish dateMar 26, 2009 (structure data deposition date)
AuthorsQing, J. / Du, X. / Chen, Y. / Chan, P. / Li, H. / Wu, P. / Marsters, S. / Stawicki, S. / Tien, J. / Totpal, K. ...Qing, J. / Du, X. / Chen, Y. / Chan, P. / Li, H. / Wu, P. / Marsters, S. / Stawicki, S. / Tien, J. / Totpal, K. / Ross, S. / Stinson, S. / Dornan, D. / French, D. / Wang, Q.R. / Stephan, J.P. / Wu, Y. / Wiesmann, C. / Ashkenazi, A.
External linksJ. Clin. Invest. / PubMed:19381019
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-3grw:
FGFR3 in complex with a Fab
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/IMMUNE SYSTEM / FGFR3 / Fab / protein-protein complex / receptor tyrosine kinase / ATP-binding / Immunoglobulin domain / Kinase / Membrane / Nucleotide-binding / Receptor / Transferase / Transmembrane / Tyrosine-protein kinase / TRANSFERASE-IMMUNE SYSTEM COMPLEX

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