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-Structure paper
Title | Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 4892-4902, Year 2009 |
Publish date | Mar 3, 2009 (structure data deposition date) |
![]() | Gangjee, A. / Li, W. / Kisliuk, R.L. / Cody, V. / Pace, J. / Piraino, J. / Makin, J. |
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Methods | X-ray diffraction |
Resolution | 1.24 - 1.53 Å |
Structure data | ![]() PDB-3ghc: ![]() PDB-3ghv: ![]() PDB-3ghw: ![]() PDB-3gi2: |
Chemicals | ![]() ChemComp-GHC: ![]() ChemComp-NDP: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-GOL: ![]() ChemComp-GHW: |
Source |
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![]() | OXIDOREDUCTASE / protein inhibitor complex folate analogues / NADP / One-carbon metabolism / dihydrofolate reductase / folate enzyme / active site mutants / human dihydrofoalte reductase inhibitor complex |