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Title | 2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 2571-2586, Year 2009 |
Publish date | Feb 27, 2009 (structure data deposition date) |
Authors | Degoey, D.A. / Grampovnik, D.J. / Flentge, C.A. / Flosi, W.J. / Chen, H.J. / Yeung, C.M. / Randolph, J.T. / Klein, L.L. / Dekhtyar, T. / Colletti, L. ...Degoey, D.A. / Grampovnik, D.J. / Flentge, C.A. / Flosi, W.J. / Chen, H.J. / Yeung, C.M. / Randolph, J.T. / Klein, L.L. / Dekhtyar, T. / Colletti, L. / Marsh, K.C. / Stoll, V. / Mamo, M. / Morfitt, D.C. / Nguyen, B. / Schmidt, J.M. / Swanson, S.J. / Mo, H. / Kati, W.M. / Molla, A. / Kempf, D.J. |
External links | J. Med. Chem. / PubMed:19323562 |
Methods | X-ray diffraction |
Resolution | 2.5 - 3.09 Å |
Structure data | PDB-3gga: PDB-3ggv: PDB-3ggx: PDB-3s85: |
Chemicals | ChemComp-GGW: ChemComp-HOH: ChemComp-GGV: ChemComp-GGX: ChemComp-LK0: |
Source |
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Keywords | HYDROLASE / pseudo-symmetrical HIV Protease Inhibitors / Protease / HIV Protease / pseudo-symmetric inhibitors / HYDROLASE/HYDROLASE INHIBITOR / Beta Barrel / Acid protease / Aspartic-type endopepidase activity / HYDROLASE-HYDROLASE INHIBITOR complex |