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TitleDiscovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 2006-2008, Year 2009
Publish dateFeb 5, 2009 (structure data deposition date)
AuthorsVan Zandt, M.C. / Doan, B. / Sawicki, D.R. / Sredy, J. / Podjarny, A.D.
External linksBioorg. Med. Chem. Lett. / PubMed:19250825
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3g5e:
Human aldose reductase complexed with IDD 740 inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-Q74:
2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / ALDOSE REDUCTASE / INHIBITION / DIABETES / Acetylation / Cataract / Cytoplasm / NADP / Phosphoprotein / Polymorphism

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