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-Structure paper
Title | Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex. |
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Journal, issue, pages | J. Biol. Chem., Vol. 284, Page 19786-19790, Year 2009 |
Publish date | Jan 30, 2009 (structure data deposition date) |
Authors | Drury, J.E. / Di Costanzo, L. / Penning, T.M. / Christianson, D.W. |
External links | J. Biol. Chem. / PubMed:19515843 |
Methods | X-ray diffraction |
Resolution | 1.701 Å |
Structure data | PDB-3g1r: |
Chemicals | ChemComp-NAP: ChemComp-FIT: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / FINASTERIDE complex / Bile acid catabolism / Cytoplasm / Disease mutation / Intrahepatic cholestasis / Lipid metabolism / NADP / Steroid metabolism |