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TitleStructure of granzyme C reveals an unusual mechanism of protease autoinhibition
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 106, Page 5587-5592, Year 2009
Publish dateJan 27, 2009 (structure data deposition date)
AuthorsKaiserman, D. / Buckle, A.M. / Van Damme, P. / Irving, J.A. / Law, R.H.P. / Matthews, A.Y. / Bashtannyk-Puhalovich, T. / Langendorf, C. / Thompson, P. / Vandekerckhove, J. ...Kaiserman, D. / Buckle, A.M. / Van Damme, P. / Irving, J.A. / Law, R.H.P. / Matthews, A.Y. / Bashtannyk-Puhalovich, T. / Langendorf, C. / Thompson, P. / Vandekerckhove, J. / Gevaert, K. / Whisstock, J.C. / Bird, P.I.
External linksProc. Natl. Acad. Sci. USA / PubMed:19299505
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-3fzz:
Structure of GrC
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3g01:
Structure of GrC mutant E192R/E193G
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / Cytolysis / Protease / Serine protease / Zymogen

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