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-Structure paper
| Title | Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration. |
|---|---|
| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 1380-1385, Year 2009 |
| Publish date | Jan 8, 2009 (structure data deposition date) |
 Authors | Lunniss, C.J. / Cooper, A.W. / Eldred, C.D. / Kranz, M. / Lindvall, M. / Lucas, F.S. / Neu, M. / Preston, A.G. / Ranshaw, L.E. / Redgrave, A.J. ...Lunniss, C.J. / Cooper, A.W. / Eldred, C.D. / Kranz, M. / Lindvall, M. / Lucas, F.S. / Neu, M. / Preston, A.G. / Ranshaw, L.E. / Redgrave, A.J. / Ed Robinson, J. / Shipley, T.J. / Solanke, Y.E. / Somers, D.O. / Wiseman, J.O. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:19195882 |
| Methods | X-ray diffraction |
| Resolution | 1.7 Å |
| Structure data |  PDB-3frg: |
| Chemicals |  ChemComp-SK4:  ChemComp-ZN:  ChemComp-MG:  ChemComp-ARS:  ChemComp-GOL:  ChemComp-HOH: |
| Source |
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 Keywords | HYDROLASE/HYDROLASE INHIBITOR / PDE / PHOSPHODIESTERASE / cAMP / Alternative splicing / Hydrolase / Phosphoprotein / Polymorphism / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |
homo sapiens (human)