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-Structure paper
Title | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. |
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Journal, issue, pages | J. Biol. Chem., Vol. 284, Page 32178-32187, Year 2009 |
Publish date | Jan 7, 2009 (structure data deposition date) |
Authors | Zhao, M. / Wan, Z.L. / Whittaker, L. / Xu, B. / Phillips, N.B. / Katsoyannis, P.G. / Ismail-Beigi, F. / Whittaker, J. / Weiss, M.A. |
External links | J. Biol. Chem. / PubMed:19773552 |
Methods | X-ray diffraction |
Resolution | 1.35 Å |
Structure data | PDB-3fq9: |
Chemicals | ChemComp-ZN: ChemComp-HOH: |
Keywords | HORMONE / receptor-binding / insulin design / rational / therapeutic implication / Carbohydrate metabolism / Cleavage on pair of basic residues / Diabetes mellitus / Disease mutation / Glucose metabolism / Pharmaceutical / Secreted |